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    Lung Cancer Program

    What is the purpose of this study?

    The main purpose of the trial is to assess whether the trial drug, KST-6051, is safe and tolerable when administered orally, alone or in combination with other anticancer agents, to adults with advanced or metastatic solid tumors with certain KRAS mutations.

    Eligibility

    1. Age ≥ 18 years.
    2. Willing and able to give written informed consent.
    3. Histologically documented locally advanced and unresectable or metastatic NSCLC, PDAC, CRC, or other solid tumor.
    4. Documentation of KRAS mutation prior to the first dose of trial drug(s).
    5. Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1.
    6. Adequate cardiovascular, hematological, liver, and renal function.
    7. Measurable disease at baseline per Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST 1.1).

    Where can I participate?

    Hoag Hospital - Newport Beach
    1 Hoag Dr
    Newport Beach, CA 92663


    Bob Doe

    firstName.lastName@hoag.org


    More about this Clinical Trial

    What is the full name of this Clinical Trial?

    A First-in-human Phase 1 Dose Escalation and Dose Expansion Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of KST-6051 in Patients With Advanced or Metastatic Solid Tumors With a KRAS Mutation

    • Age GroupAdult, Older Adult
    • PhaseI
    • IRB NumberSTUDY00004948
    • ClinicalTrials.gov IDNCT07458347

    World-Class Lung Cancer Team

    Hoag’s unparalleled expertise, groundbreaking research and range of treatment options enable us to deliver a treatment plan designed for each person. Our multidisciplinary team of medical oncologists, surgical oncologists, radiation oncologists, interventional pulmonologists and other cancer specialists provides you with a comprehensive approach to help you survive cancer, heal and move forward with your life.
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    OC’s Only Practicing Fellowship-Trained Interventional Pulmonologist

    Our expert team boasts the only interventional pulmonologist in Orange County, who is triple board-certified and has specialized expertise in robotic and minimally invasive approaches.
    Learn more about Interventional Pulmonology at Hoag
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    Now Offering Cios Spin®, a Groundbreaking Diagnostics Tool

    Hoag continues to introduce the most advanced diagnostics and treatment options available for lung cancer. In fact, Hoag is the first hospital in Orange County to offer Cios Spin®, a technology that diagnoses lung cancer earlier, more accurately and less invasively – so you can get back to your life that much sooner. Our innovative diagnosis and treatment technologies include: Cios Spin, the Ion Robotic-Assisted Bronchoscopy Platform, Endobronchial Ultrasound (EBUS) and Ion Navigational Bronchoscopy.
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    OC’s Robotic Surgery Experts for Lung Cancer

    Hoag’s robotic program offers state-of-the-art technology and expertly trained, board-certified lung cancer surgeons. Our robotic surgical options for lung cancer offer many benefits: minimally invasive, enhanced precision, improved dexterity, reduced complications, shorter recovery time.
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    Defying the Odds with Early-Phase Clinical Trials

    Hoag Family Cancer Institute is a leader in lung cancer research, giving patients options that are unavailable at other local hospitals. With an extensive Phase 1 Clinical Trials Program, we offer comprehensive clinical trials for all solid tumor cancers. Our clinical trials in precision medicine, molecular imaging and therapy, and immunotherapy/cell therapy, among others, provide groundbreaking treatments that are helping to beat the odds against lung cancer.
    Learn About Enrolling Clinical Trials for Lung Cancer
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    Most Advanced Radiation Treatment Available

    Stereotactic Body Radiation Therapy (SBRT) delivers a very focused, high dose of radiation to the lung cancer site with the goal of killing all cancer cells in the area. Hoag uses the most advanced radiation treatment available in the U.S. – ViewRay MRIdian™ linear accelerator. This technology, combined with an exceptional level of expertise, allows our radiation oncology team to precisely capture real-time, high-resolution images of a patient’s tumor during treatment to ensure only the cancer is destroyed.
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